The Ligament Injury-Osteoarthritis Connection: The Role of Prolotherapy in Ligament Repair and the Prevention of Osteoarthritis
By Mark Wheaton, MD, Journal of Prolotherapy, 2011
A review of past and current literature has provided ample evidence to definitively support the connection between ligament injury and joint instability and the development of degenerative osteoarthritis of peripheral joints and the spine.
Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review
By Carlos Meheux,MD, Arthroscopy, 2015
In patients with symptomatic knee OA, PRP injection results in significant clinical improvements up to 12 months postinjection.
Platelet Rich Plasma Prolotherapy for Rotator Cuff Tears
By Donna Alderman, DO, Practical Pain Management, 2012
Physicians should consider platelet rich plasma prolotherapy for patients with tendinopathies or rotator cuff tears before any surgical interventions.
Long-term effects of dextrose prolotherapy for anterior cruciate ligament laxity
By Dean Reeves, MD, Alternative Medicine Health Journal, 2013
In patients with symptomatic anterior cruciate ligament laxity, intermittent dextrose injection resulted in clinically and statistically significant improvement in ACL laxity, pain, swelling, and knee range of motion.
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Sclerotherapy of Baker's cyst with imaging confirmation of Resolution
By Chris Centeno, MD, Pain Physician, 2008
Prolotherapy is an effective treatment for Baker's cyst
Platelet-rich Plasma: Intra-articular Knee Injections Produce Favorable Results on Degenerative Cartilage Lesions
By Giuseppe Filardo, MD, Knee Surg Sports Traumatol Arthrosc , 2010
Intra-articular knee injections with PRP is safe and has the potential to reduce pain and improve knee function and quality of life
in younger patients with low degree of articular degeneration.
The Efficacy of Dextrose Prolotherapy for Temporomandibular Joint Hypermobility
By Hamida Refai, MD, Oral Maxillofacial Surgery, 2011
Prolotherapy appears promising for the treatment of TMJ hypermobility. It is simple, safe, and lacks significant side effects.
Subcutaneous Prolotherapy for Refractory Knee, Shoulder and Elbow Pain
By John Lyftogt, MD, Australasian Musculoskeletal Medicine, 2007
Patient satisfaction rates at follow up were 91.7%. The treatment was well tolerated and safe.
Regenerative Injection of Elite Athletes With Career-Altering Chronic Groin Pain
By Gaston Topol, MD, Am J Physical Medicine and Rehabilitation, 2008
Athletes returned to full elite-level performance in a timely and sustainable manner after regenerative injection therapy using dextrose.
A Retrospective Study on Hackett-Hemwall Dextrose Prolotherapy for Chronic Shoulder Pain
By Ross Hauser, MD, Journal of Prolotherapy, 2009
Patients with chronic shoulder pain reported significant improvements in many clinically relevant parameters and overall quality of life after recieving Hackett-Hemwall dextrose prolotherapy
Dextrose Prolotherapy for Osteoarthritic Thumbs and Fingers
By Dean Reeves, MD, Journal of Alternative and Complimentary Medicine, 2000
This study demonstrates that intra-articular 10% dextrose appears to be clinically effective and safe in the treatment of finger osteoarthritis pain and joint stiffness.
Evidence-Based Regenerative Injection Therapy(Prolotherapy) in Sports Medicine
By Dean Reeves, MD, Sports Medicine Resource Manual, 2008
Suboptimal tissue healing leaves the athlete with a decrease in tensile strength of the damaged tissue or relative laxity, these
effects increase susceptibility of the athlete to repetitive injury or rupture, and can inhibit full performance.
Dextrose Prolotherapy for Knee Osteoarthritis: A Randomized Controlled Trial
By David Rabago, MD, Annals of Family Medicine, 2013
Prolotherapy resulted in clinically meaningful sustained improvement of pain, function, and stiffness scores for knee osteoarthritis compared with blinded saline injections and at-home exercises.
The Effects of Dextrose Prolotherapy in Symptomatic Knee Osteoarthritis:
A Randomized Controlled Study
By Alketa T. Sert, Ekin I. Sen, Sina Esmaeilzadeh, and Emel Ozcan,
The Journal of Alternative and Complementary Medicine, 2019
Findings suggest that dextrose prolotherapy is effective at reducing pain and improving the functional status and quality of life of patients with Knee Osteoarthritis.
Ongoing Positive Effect of Platelet-Rich Plasma Versus Corticosteroid Injection for Epicondylitis
Treatment of patients with chronic tennis elbow with PRP reduces pain and increased function significantly, exceeding the effect
of corticosteroid injection even after a follow-up of 2 years.