Dextrose Prolotherapy for Osteoarthritic Thumbs and Fingers

By Dean Reeves, MD, Journal of Alternative and Complimentary Medicine, 2000

​This study demonstrates that intra-articular 10% dextrose appears to be clinically effective and safe in the treatment of finger osteoarthritis pain and joint stiffness. 

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The Ligament Injury-Osteoarthritis Connection: The Role of Prolotherapy in Ligament Repair and the Prevention of Osteoarthritis

By Mark Wheaton, MD, Journal of Prolotherapy, 2011

A review of past and current literature has provided ample evidence to definitively support the connection between ligament injury and joint instability and the development of degenerative osteoarthritis of peripheral joints and the spine.

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Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review

By Carlos Meheux, MD, Arthroscopy, 2015

In patients with symptomatic knee OA, PRP injection results in significant clinical improvements up to 12 months postinjection.

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Platelet Rich Plasma Prolotherapy for Rotator Cuff Tears

By Donna Alderman, DO, Practical Pain Management, 2012

Physicians should consider platelet rich plasma prolotherapy for patients with tendinopathies or rotator cuff tears before any surgical interventions.

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RVHC: 720-875-2880

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Long-term effects of dextrose prolotherapy for anterior cruciate ligament laxity

By Dean Reeves, MD, Alternative Medicine Health Journal, 2013

In patients with symptomatic anterior cruciate ligament laxity, intermittent dextrose injection resulted in clinically and statistically significant improvement in ACL laxity, pain, swelling, and knee range of motion.

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Sclerotherapy of Baker's cyst with imaging confirmation of Resolution

By Chris Centeno, MD, Pain Physician, 2008

Prolotherapy is an effective treatment for Baker's cyst

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Rocky Vista Health Center

8401 S. Chambers Road

Parker, Co 80134

Platelet-rich Plasma: Intra-articular Knee Injections Produce Favorable Results on Degenerative Cartilage Lesions

By Giuseppe Filardo, MD, Knee Surg Sports Traumatol Arthrosc , 2010

 Intra-articular knee injections with PRP is safe and has the potential to reduce pain and improve knee function and quality of life

in younger patients with low degree of articular degeneration.

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The Efficacy of Dextrose Prolotherapy for Temporomandibular Joint Hypermobility

By Hamida Refai, MD, Oral Maxillofacial Surgery, 2011

Prolotherapy appears promising for the treatment of TMJ hypermobility. It is simple, safe, and lacks significant side effects.

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Regenerative Injection of Elite Athletes With Career-Altering Chronic Groin Pain

By Gaston Topol, MD, Am J Physical Medicine and Rehabilitation, 2008

Athletes returned to full elite-level performance in a timely and sustainable manner after regenerative injection therapy using dextrose.

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Subcutaneous Prolotherapy for Refractory Knee, Shoulder and Elbow Pain

By John Lyftogt, MD, Australasian Musculoskeletal Medicine, 2007

Patient satisfaction rates at follow up were 91.7%. The treatment was well tolerated and safe.  

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Dextrose Prolotherapy for Knee Osteoarthritis: A Randomized Controlled Trial

By David Rabago, MD, Annals of Family Medicine, 2013

Prolotherapy resulted in clinically meaningful sustained improvement of pain, function, and stiffness scores for knee osteoarthritis compared with blinded saline injections and at-home exercises.

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A Retrospective Study on Hackett-Hemwall Dextrose Prolotherapy for Chronic Shoulder Pain

By Ross Hauser, MD, Journal of Prolotherapy, 2009 

 Patients with chronic shoulder pain reported significant improvements in many clinically relevant parameters and overall quality of life after receiving Hackett-Hemwall dextrose prolotherapy

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Evidence-Based Regenerative Injection Therapy(Prolotherapy) in Sports Medicine

​By Dean Reeves, MD, Sports Medicine Resource Manual, 2008

 Suboptimal tissue healing leaves the athlete with a decrease in tensile strength of the damaged tissue or relative laxity, these

effects increase susceptibility of the athlete to repetitive injury or rupture, and can inhibit full performance. 

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Ongoing Positive Effect of Platelet-Rich Plasma Versus Corticosteroid Injection for Epicondylitis

By Taco Gosens, MD, American Journal of Sports Medicine, 2011

 Treatment of patients with chronic tennis elbow with PRP reduces pain and increased function significantly, exceeding the effect

of corticosteroid injection even after a follow-up of 2 years.

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The Effects of Dextrose Prolotherapy in Symptomatic Knee Osteoarthritis:

A Randomized Controlled Study

By Alketa T. Sert, Ekin I. Sen, Sina Esmaeilzadeh, and Emel Ozcan,

​The Journal of Alternative and Complementary Medicine, 2019

Findings suggest that dextrose prolotherapy is effective at reducing pain and improving the functional status and quality of life of patients with Knee Osteoarthritis.

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